Association of propionate with coronary artery disease in a large cross-sectional study
نویسندگان
چکیده
Abstract Background Microbiome has been linked to the pathogenesis of coronary artery disease (CAD) but data providing direct evidence for an association short-chain fatty acids (SCFA) like propionate with CAD are lacking. Purpose To study in blood samples presence Methods This was a cross-sectional enrolling patients admitted invasive angiography university hospital Germany. Patients were prospectively recruited between from March 2017 January 2020. known or suspected and risk factors cardiovascular diseases screened eligibility participate trial. Main exclusion criteria inflammatory/rheumatic disease, active cancer acute infection. Blood sampling performed after overnight fasting before procedures. Measurement though liquid chromatography. Results The included 691 (median n [IQR] age, 69 [60–78] years; 406 men [59%]). A total 368 had invasively confirmed at least one stenosis ≥50% 323 non 194 excluded CAD. 129 additional without suspicion diabetes/smoking also no group. significant lower levels (median) 6.08 μM (IQR, 4.31–7.65) compared groups 6.92 (4.89–9.25, <0.05). Linear regression multivariate analysis adjusted gender, body mass index, hypertension, smoking, diabetes hyperlipidemia revealed odds ratio 0.92 (CI 0.89–0,96, p<0.001) as predictor Conclusions provides large-scale protective role development CAD, independent other factors. Funding Acknowledgement Type funding sources: Private grant(s) and/or Sponsorship. source(s): Internal Grant, Medical School Brandenburg
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2022
ISSN: ['2634-3916']
DOI: https://doi.org/10.1093/eurheartj/ehac544.2347